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Indeed, acute suppression of PrP in the liver of Atp7b −/− mice via siRNA injection resulted in a significant decrease in Cu, supporting the role of PrP in hepatic Cu uptake (Supplementary Fig
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In Schneider-Helmert's human studies (1985, European Archives of Psychiatry and Neurological Sciences), small cohorts of insomnia patients received DSIP via IV and showed some shifts in sleep stage architecture measured by polysomnography, but results were not consistent across all subjects and the studies lacked the statistical power of modern RCTs
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