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For some biological effects the duration of NO production is decisive because certain target molecules bind NO very slowly or need sequential NO and ROS modifications (Thomas et al., 2008)
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TK) or UL30 (DNA polymerase) genes, coupled with limited bioavailability and potential cytotoxicity, underscores the urgent need for novel antiviral agents with distinct molecular targets and improved pharmacokinetic and pharmacodynamic profiles [28,29,30,31,32]
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