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However, only the Ξ± 1A -AR subtype, when translocated to deeper endosomes, induces a sustained activation of ERK1/2, which was abrogated by Ξ² -arrestin 2 knockdown or with the use of the endocytosis inhibitor concanavalin A (Perez-Aso et al., 2013
Tribedoce
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It is thought that hormonal changes such as this hypocortisolism may result in symptoms of fatigue experienced by patients (255, 428, 429)
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