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What exists instead is a set of downstream pathway observations: sensitivity of effects to manipulation of the nitric oxide system, reported changes in VEGFR2 expression and signaling and in angiogenic readouts, reported changes in early growth response 1 and in focal adhesion kinase and paxillin, and behavioral work involving dopaminergic and serotonergic challenge agents
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On the other hand, replacing red meat with fish, shellfish, or eggs was found to reduce the risk of the disease
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