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Both GSSG and GSH are substrates for the gamma-glutamyl cycle, which promotes the intracellular transfer of cysteine from plasma glutathione (GSH or GSSG) with a view to the new cellular synthesis of glutathione [25]
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Introduction Amino acid metabolism is altered in many cancers, reflecting cancer cell uptake and altered metabolic needs, and targeting these pathways is becoming an attractive approach to patient therapy ( de novo or recycled through protein degradation ( de novo biosynthesis or a catabolic supply of cysteine is not sufficient to meet the high demand for antioxidant synthesis
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