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The Feasibility and Efficacy of a Brief Integrative Treatment for Adults With Depression and/or Anxiety: A Randomized Controlled Trial
This null result in a well-powered trial effectively closed the IGF-1 hypothesis of Alzheimer’s neuroprotection as a viable research direction for MK-677, at least via the mechanism tested
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Studies show that α -synuclein may bind iron directly, promoting its aggregation, while lipid peroxidation products further stabilize toxic oligomers (Wang et al., 2023
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