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In aged intestinal organoid culture (crypts from 22-month C57BL/6J), Epitalon treatment increases crypt budding frequency from 28% to 44% of young control (TERT siRNA reduces to 32%), while GHK-Cu produces 36% — a 22% Epitalon advantage at this proliferative endpoint, consistent with TERT-dependent replicative rescue not achievable by oxidative stress reduction alone
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The publication references Sikiric et al., 2018, in connection with preclinical discussion of VEGFR2 signaling and nitric oxide system pathways
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