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Medical management Treatment of renal colic and medical expulsive therapy Treatment of the pain associated with kidney stones (renal colic) is based on the use of NSAIDs as a first choice in the absence of contraindications 229,230 and, in case of failure in relieving pain, opioids
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Second, and in parallel, FIN56 leads to the depletion of coenzyme Q10 (CoQ10), a crucial lipophilic radical-trapping antioxidant that functions as a key component of the FSP1-CoQ10-NAD(P)H axis, an independent anti-ferroptotic system that operates in parallel to the GPX4 pathway
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