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The complexity of this biology was further realized, where primary astrocytes in response to EAE modeling by LPS and IFNγ supplementation, showed activation of the salvage pathway, rather than the kynurenine pathway, and FK866 similarly blunted astrocytic inflammation (72)
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Mechanistically, GHK-Cu has been shown to stimulate collagen and elastin synthesis in dermal fibroblasts, increase decorin (a small proteoglycan that helps regulate collagen organization), and influence matrix metalloproteinases and their inhibitors
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