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Under such circumstances secondary oxidative pathways can be triggered that divert the typical non-toxic metabolic sequence and NM formation to allow the generation of the intermediates, such as dopamine- o -quinone and dopaminochrome, which can subsequently generate further metabolites, such as leukodopamineochrome- o -semiquinone that are considered powerful endogenous neurotoxins consequent to an ability to reduce oxygen to a superoxide radical anion, giving rise to redox cycling and producing acute toxicity [26]
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