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Once embedded in the ER phospholipid bilayer, 4-HNE disrupts membrane integrity and inhibits sarco/endoplasmic reticulum Ca 2+ -ATPase 2b (SERCA2b) activity, leading to excessive Ca 2+ leakage from the ER lumen (Tashkandi et al., 2025)
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showed increased levels of malondialdehyde (MDA), nitric oxide (NO), and elevated enzymatic activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the serum of melasma patients compared to controls [11]
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