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Intriguingly, in the context of breast cancer, the blockade of other metabolic pathways involving MMA or the activation of MMA production, coupled with vitamin B 12 intracellular deficiency, resulted in enhanced tumor metastasis [174,189]
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Genetic susceptibility likely interacts with prenatal and early-life environmental adversities, disrupting synaptogenesis, myelination, and large-scale network development, which may manifest as lower premorbid IQ and developmental delays (209)
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