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Moreover, some synthetic surfactants used for functionalization exhibit dose-dependent cytotoxicity or immunogenicity, especially in chronic administration scenarios, raising significant regulatory scrutiny [113]
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Exposure of RAW 264.7 cells to LPS for four hours dramatically increased the secretion of IL-6 to 613.2 ± 35.1 pg/ml and TNF-α to 1556.3 ± 23.3 pg/ml
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