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Figure 1 Figure 2 Analysis of Vasculature in In Vivo and In Vitro Models Vasculature has been explored for many decades and the application of in vitro and in vivo assays to evaluate the induction and inhibition of vascularization has exerted a significant role for researchers to study and understand angiogenesis ( in vitro models, such as the model of ECs, are easily analyzed and reproducible, yet the cells become senescent in the culture after a few passages ( in vitro models, in vivo models, for example, the model of chick chorioallantoic membrane (CAM), owns the advantages of short experimental period and low cost, which is available for drug screening ( in vivo model is xenograft tumor in mice