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In both VEGFR1 and VEGFR2, extracellular domains 2 (D2) and 3 (D3) are critical for VEGF-A recognition: ligand binding triggers conformational changes that are postulated to be transmitted through the transmembrane region to cause TK activation [66]

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In particular, in autosomal recessive PD genes, pathogenic PRKN p.R256C and PINK1 p.A339T (in heterozygous state) were detected in the same individual with another probably benign variant