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This makes the glutamate/GABA‐glutamine cycle a fascinating subject to study, but also complicates the mechanistic delineations when the cycle is malfunctioning e.g

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Mutation of the A2’ helices in cyclins D1, D2, and D3 had similar effects and reduced the ability of these kinase complexes to phosphorylate Rb by 5.3±0.1-fold, 12.0±0.06-fold, and 15.9±0.5-fold, respectively, compared to wild-type ( Fig