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This activation is attained via Toll-like receptors (TLRs) and is followed by the release of ROS and neutrophil extracellular traps (NETs) from neutrophils, which only aggravates the immune response [136]

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The search terms of the investigation were “aging,” “antimicrobial,” “antioxidant,” “diabetes mellitus,” “dry eye,” “exocrine gland,” “hormone,” “insulin,” “lacrimal gland,” “lactoperoxidase,” “ocular surface,” “oxidative stress,” “peroxidase,” “saliva,” “sex,” “superoxide dismutase,” “tears” and “tear film.” Our search was extensive, with articles written in English and not limited to the year of publication