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Cyclophosphamide (CTX), ara-C and topotecan (TOP)(CAT) in patients (pts) with refractory or relapsed acute leukemias and transformed chronic myelogenous leukemia (CML)
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357,358 Thus, combinatorial strategies that block downstream pro-metastatic cytokines (e.g., IL-6 or CXCL8) or macrophage reprogramming may uncouple necroptosis from its deleterious consequences
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