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Nebulised treatment should be considered for patients with distressing or disabling breathlessness despite maximal use of inhalers, and continued if an improvement is seen in symptoms, ability to undertake activities of daily living, exercise capacity, or lung function

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Compared to transplantation of transfected cells, direct gene transfer is less invasive, inducing minimal disturbance of synaptic circuitry and does not involve risk of unregulated cellular proliferation or undesired delivery of cell byproducts

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