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The author proposed that enhanced PKA activity inhibits cRaf-1 (a proto-oncogene serine/threonine-protein kinase) by phosphorylation at serine259, decreasing nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) activity and the expression of NFκB-controlled genes such as BACE1 in the hippocampus of treated AD Tg mice (Arendash et al., Swe mice (Zeitlin et al., 2011)

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Size:1000 mcg/ml - 10 ml x 5

Disclosures: Vinay Jahagirdar: Nothing to Disclose, Waqas Rasheed: Nothing to Disclose, Hanna Blaney: Nothing to Disclose, Hassam Ali: Nothing to Disclose, Jasmohan Bajaj: Bausch: Grant/Research Support, Sequana: Grant/Research Support, Cosmo: Grant/Research Support, Grifols: Grant/Research Support 2290 SIMVASTATIN INEFFECTIVE IN IMPROVING HEPATOPULMONARY SYNDROME IN CIRRHOSIS PATIENTS (HEPSIM TRIAL) – RESULTS OF A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL [NCT05187715] Akhil Deshmukh 1 Shiv Kumar Sarin 1 Vishnu Girish 1 CHITRANSHU VASHISHTHA 1 Sukriti Baweja 1 Tushar Madke 1 Rahul khajuria 1 Harsh Tevethia 2 , 1 Institute Of Liver and Biliary Sciences, 2 INSTITUTE OF LIVER AND BILIARY SCIENCES(ILBS),NEW DELHI Background: Hepatopulmonary syndrome (HPS), marked by liver disease, intrapulmonary vascular dilatations, and abnormal oxygenation, causes significant morbidity and mortality