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High-Priority Drug Interactions# Oral Contraceptives# Evidence level: Formal PK studies conducted Semaglutide pharmacokinetic studies showed: Delayed Tmax for oral ethinyl estradiol and levonorgestrel by approximately 0.5-1 hour Overall bioavailability (AUC) was not significantly reduced Clinical guidance: Current evidence suggests GLP-1 agonists do not meaningfully reduce oral contraceptive efficacy
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Additionally, it is an important pathway in activating the nuclear transcriptional factor NF-κB 78
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