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This was consistently visualized with different endothelial cell antigens, FVIII (involved in platelet adhesion and aggregation, present on endothelial cells of mature blood vessels) and CD34 (involved in leukocyte adhesion and endothelial cell migration during angiogenesis, present on capillary endothelial cells), as well as with VEGF presentation (main factor in angiogenesis, expressed on endothelial cells, mitogen for vascular endothelial cells)
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The aphenotypic nature of gr1 mutants is due to the ‘back-up’ GSSG regeneration activity by the cytosol-located NTR-TRX system (Marty et al., 2009)
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