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In the late 1950s, a drug called thalidomide was widely prescribed in Europe and Australia as a highly effective treatment for morning sickness in pregnant women. The manufacturer assured doctors that the

This phenomenon is further complicated by reported no observed adverse effect levels (NOAELs) that vary by 2–3 orders of magnitude across studies, likely reflecting differences in metabolic processing, genetic susceptibility, and methodological approaches ( 1.3 Objectives of this review This comprehensive review synthesizes current evidence (2019–2024) regarding EED-mediated reproductive toxicity in males, with particular emphasis on: Mechanistic Understanding: Elucidating the molecular pathways through which EEDs disrupt male reproductive function, including oxidative stress cascades, endocrine signaling interference, and epigenetic modifications

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and studies not published in English