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Kruse and colleagues resulted in selection of cagrilintide (compound 23 in their medicinal chemistry series) for clinical advancement based on its superior stability profile, extended half-life, and potent appetite-suppressing effects in preclinical models
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Pentameric nCRP and CRP peptides 77–82, 174–185, and 201–206 can control the inflammatory response resolving inflammation by reducing inflammatory cell endothelial adhesion and tissue migration, and the described CRP-mediated enhanced monocyte chemotaxis could be explained by local generation of mCRP (190, 191)
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