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While polygenic risk scores (PRS) address part of this architecture by aggregating validated risk alleles from GWAS, the proposed workflow further considers the potential cumulative burden of variants typically deemed benign, aiming to bridge the gap between population-level risk estimation and individualized interpretation (Torkamani et al., 2018)
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Otherwise, intestinal ischemia[59] appears as the final consequence of blood pooling in the splanchnic bed, inducing portal hypertension, and multivisceral edema, and mesenterial venous occlusion, could also induce intestinal injury as early as within 5 min
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