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One of these neurotoxins, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), is commonly used in an experimental PD model in vivo [105]
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Tolerance, or tolerance withdrawal: When the receptors in the brain become adapted or accustomed to the action of the original dose of BZ, more of the drug is needed for the desired therapeutic effect (or the original effect at the original dose) to be achieved
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