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SLC39A9-mediated Zn 2+ transport, but not C3orf58 kinase activity, is necessary for α-syn-PFFs accumulation Because C3orf58 and SLC39A9 deficiency specifically reduced the accumulation of α-syn PFFs but not that of other cargoes, including Tau oligomers, we decided to study more in detail the mode of action of these two genes
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These types of dissimilarities could, at least partially, explain species-specific differences in dopaminergic immunomodulatory effects
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