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The idea that mature fibrils are substantially inert, harmless deposits of the toxic precursors implies that their growth has the significance of a cell defense mechanism and contributes toward explaining the lack of direct correlation between the load of amyloid plaques in human AD brain and the severity of the clinical symptoms [42]
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Aside from its crucial function in the glutathione redox cycle, riboflavin also indirectly safeguards against ROS by serving as a coenzyme for xanthine oxidase [62]
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