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Acetaldehyde also disrupts barrier function, which is inhibited by pretreatment of EGF through the activation of EGF receptor-phospholipase-γ-PKCβ1/ε and EGF receptor-MEK/ERK signaling pathways.57 8
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These studies raise the possibility of Hx-based therapeutics in the treatment of diverse pathologies in which heme-mediated tissue damage play an etiopathogenetic role
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