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63 While appending CPPs to MCPs is useful for improving bioactivity, there have been no therapeutics containing a CPP approved by the FDA to date, likely due to potential for cellular toxicity, adverse immune response, and poor efficacy arising from the lack of specificity due to the CPP moiety
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However, there was no significant difference in carbonyl contents between WT(pXMJ19) cells and WT(pXMJ19-His 6 - mtr ) cells treated with rifamycin SV and formaldehyde
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